Reevaluation of the risk of fetal death and malformation after Q Fever

Matthieu Million; France Roblot; Dominiques Carles; Felicetta D'Amato; Camelia Protopopescu; Maria Patrizia Carrieri; Didier Raoult

doi:10.1093/cid/ciu259

Reevaluation of the risk of fetal death and malformation after Q Fever

Clin Infect Dis. 2014 Jul 15;59(2):256-60. doi: 10.1093/cid/ciu259. Epub 2014 Apr 18.

Authors

Matthieu Million¹, France Roblot², Dominiques Carles³, Felicetta D'Amato¹, Camelia Protopopescu⁴, Maria Patrizia Carrieri⁴, Didier Raoult¹

Affiliations

¹ Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille.
² Service de Maladies Infectieuses, Hôpital La Milétrie, INSERM 1070, Poitiers.
³ Service d'Anatomie Pathologique, Université de Bordeaux.
⁴ INSERM, UMR912 (SESSTIM) Aix Marseille Université, UMR_S912, IRD ORS PACA, Observatoire Régional de la Santé Provence-Alpes-Côte-d'Azur, Marseille, France.

PMID: 24748522
DOI: 10.1093/cid/ciu259

Abstract

A meta-analysis of 136 Q fever pregnancies, including 4 new cases and 7 population-based serological studies, revealed significant increases in fetal death and malformation after Q fever during pregnancy. This poor obstetric outcome is prevented by antibiotic treatment.

Keywords: Coxiella burnetii; Q fever; fetal death; fetal malformation; pregnancy.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anti-Bacterial Agents / therapeutic use
Child
Congenital Abnormalities / etiology*
Female
Fetal Death*
Humans
Incidence
Middle Aged
Pregnancy
Pregnancy Complications, Infectious / drug therapy
Pregnancy Complications, Infectious / microbiology*
Q Fever / complications*
Q Fever / drug therapy
Treatment Outcome
Young Adult

Substances

Anti-Bacterial Agents