Radiation synthesis and characterization of hyaluronan capped gold nanoparticles

Nguyen Quoc Hien; Dang Van Phu; Nguyen Ngoc Duy; Le Anh Quoc

doi:10.1016/j.carbpol.2012.03.041

Radiation synthesis and characterization of hyaluronan capped gold nanoparticles

Carbohydr Polym. 2012 Jun 20;89(2):537-41. doi: 10.1016/j.carbpol.2012.03.041. Epub 2012 Mar 23.

Authors

Nguyen Quoc Hien¹, Dang Van Phu, Nguyen Ngoc Duy, Le Anh Quoc

Affiliation

¹ Research and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Linh Xuan Ward, Thu Duc District, Ho Chi Minh City, Viet Nam.

PMID: 24750755
DOI: 10.1016/j.carbpol.2012.03.041

Abstract

Gold nanoparticles (AuNPs) with diameter from 4 to 10nm, capping by hyaluronan (HA) were synthesized using a γ-irradiation method. The maximum absorption wavelengths at 517-525 nm of colloidal AuNPs/HA solutions were measured by UV-vis spectroscopy. The size and size distribution of AuNPs were determined from TEM images. The influence of various factors on the size of AuNPs particularly the concentration of Au3+ and HA, and dose rate were also investigated. Results indicated that higher dose rate and HA concentration favor smaller sizes of AuNPs whereas the size increases with Au3+ concentration. The colloidal AuNPs/HA solution was fairly stable more than 6 months under storage at ambient condition. The AuNPs stabilized by biocompatible HA with the size less than 10nm as prepared can potentially be applied in biomedicines and cosmetics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gamma Rays*
Gold / chemistry
Gold / radiation effects*
Hyaluronic Acid / chemistry
Hyaluronic Acid / radiation effects*
Metal Nanoparticles / chemistry
Metal Nanoparticles / radiation effects*

Substances

Gold
Hyaluronic Acid