Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy

J Allergy Clin Immunol. 2014 Jun;133(6):1753-5.e3. doi: 10.1016/j.jaci.2014.03.032. Epub 2014 Apr 24.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / therapeutic use
  • Child
  • Child, Preschool
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Female
  • Guanine Nucleotide Exchange Factors / deficiency*
  • Herpesviridae Infections / diagnosis
  • Herpesviridae Infections / drug therapy
  • Herpesviridae Infections / immunology
  • Homozygote
  • Humans
  • Immunophenotyping
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use
  • Mutation
  • Recombinant Proteins / therapeutic use
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / immunology
  • Treatment Outcome

Substances

  • Antiviral Agents
  • DOCK8 protein, human
  • Guanine Nucleotide Exchange Factors
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins