Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain

Masaki Kato; Kazuo Okanoya; Taku Koike; Erika Sasaki; Hideyuki Okano; Shigeru Watanabe; Atsushi Iriki

doi:10.1016/j.bandl.2014.03.007

Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain

Brain Lang. 2014 Jun:133:26-38. doi: 10.1016/j.bandl.2014.03.007. Epub 2014 Apr 24.

Authors

Masaki Kato¹, Kazuo Okanoya², Taku Koike³, Erika Sasaki⁴, Hideyuki Okano⁵, Shigeru Watanabe⁶, Atsushi Iriki⁷

Affiliations

¹ Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Laboratory for Biolinguistics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Center for Advanced Research on Logic and Sensibility (CARLS), Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan. Electronic address: makatou@brain.riken.jp.
² Laboratory for Biolinguistics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
³ Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
⁴ Department of Applied Developmental Biology, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki, Kanagawa 210-0821, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; KEIO-RIKEN Research Center for Human Cognition, Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan.
⁵ Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; KEIO-RIKEN Research Center for Human Cognition, Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan; Keio University Joint Research Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
⁶ KEIO-RIKEN Research Center for Human Cognition, Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan; Center for Advanced Research on Logic and Sensibility (CARLS), Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan.
⁷ Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; KEIO-RIKEN Research Center for Human Cognition, Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan; Center for Advanced Research on Logic and Sensibility (CARLS), Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan. Electronic address: iriki@brain.riken.jp.

PMID: 24769279
DOI: 10.1016/j.bandl.2014.03.007

Abstract

Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.

Keywords: Common marmoset; Dyslexia; Gene expression; Language; Specific language impairment; Vocal communication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Animals
Brain
Brain Chemistry*
Callithrix / genetics*
Callithrix / physiology
Disease Models, Animal*
Dyslexia / genetics
Dyslexia / physiopathology
Female
Forkhead Transcription Factors / genetics
Gene Expression Profiling*
Humans
In Situ Hybridization
Language
Language Disorders / genetics*
Language Disorders / physiopathology
Male
Membrane Proteins / genetics
Microtubule-Associated Proteins / genetics
Nerve Tissue Proteins / genetics
Reading*
Receptors, Immunologic / genetics
Repressor Proteins / genetics
Roundabout Proteins
Speech / physiology*
Speech Disorders / genetics*
Speech Disorders / physiopathology

Substances

CNTNAP2 protein, human
DCDC2 protein, human
FOXP1 protein, human
FOXP2 protein, human
Forkhead Transcription Factors
KIAA0319 protein, human
Membrane Proteins
Microtubule-Associated Proteins
Nerve Tissue Proteins
Receptors, Immunologic
Repressor Proteins