Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections

Pediatr Infect Dis J. 2014 Oct;33(10):e270-2. doi: 10.1097/INF.0000000000000385.

Abstract

This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics*
  • Cerebrospinal Fluid / chemistry
  • Cerebrospinal Fluid Shunts / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Meningitis, Bacterial / drug therapy*
  • Prospective Studies
  • Vancomycin / administration & dosage
  • Vancomycin / pharmacokinetics*

Substances

  • Anti-Bacterial Agents
  • Vancomycin