Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Richard J Ingham; Claudio Battilocchio; Joel M Hawkins; Steven V Ley

doi:10.3762/bjoc.10.56

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Beilstein J Org Chem. 2014 Mar 12:10:641-52. doi: 10.3762/bjoc.10.56. eCollection 2014.

Authors

Richard J Ingham¹, Claudio Battilocchio¹, Joel M Hawkins², Steven V Ley¹

Affiliations

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
² Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA.

Abstract

Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.

Keywords: automation; flow chemistry; hydration; hydrogenation; sustainable processing.