Synthesis of carbohydrate methyl phosphoramidates

Org Lett. 2014 May 2;16(9):2518-21. doi: 10.1021/ol500894k. Epub 2014 Apr 16.

Abstract

A two-step route for introducing methyl phosphoramidate moieties onto carbohydrates is reported. The approach uses methyl pivolyl H-phosphonate as the phosphorylating reagent to produce an isolable carbohydrate H-phosphonate intermediate that is then oxidized by a Todd-Atherton reaction. The stability of the product methyl phosphoramidates was subsequently evaluated using various deprotection strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Carbohydrates / chemical synthesis*
  • Carbohydrates / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Phosphoric Acids / chemical synthesis*
  • Phosphoric Acids / chemistry
  • Phosphorylation

Substances

  • Amides
  • Carbohydrates
  • Phosphoric Acids
  • phosphoramidic acid