Association of N-terminal pro-brain natriuretic peptide and hemodynamic parameters measured by impedance cardiography in patients with essential hypertension

Clin Exp Hypertens. 2015;37(2):148-54. doi: 10.3109/10641963.2014.913611. Epub 2014 Apr 30.

Abstract

The aim of this study was to evaluate the association of NT-proBNP with clinical and hemodynamic assessment in 156 patients with arterial hypertension. NT-proBNP correlated positively with, i.e. age (r=0.310, p=0.00008), mean blood pressure (MBP; r=0.199, p=0.0136), Heather index (HI; r=0.375, p<0.00001) and negatively with thoracic fluid content (TFC; r=-0.300, p=0.0002). The patients with higher NT-proBNP were older (46.1 versus 40.6 years, p=0.001), with higher MBP (102.6 versus 98.5 mm Hg, p=0.0043), HI (14.54 versus 11.93 Ohm s2, p=0.009) and lower TFC (27.5 versus 29.4 1/kOhm, p=0.0032). The independent predictors of higher NT-proBNP were: age, MBP and HI.

Keywords: Amino-terminal pro-brain natriuretic peptide; cardiovascular system; hemodynamics; hypertension; impedance cardiography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cardiography, Impedance / methods
  • Disease Progression
  • Echocardiography
  • Essential Hypertension
  • Female
  • Follow-Up Studies
  • Hemodynamics / physiology*
  • Humans
  • Hypertension / blood*
  • Hypertension / diagnosis
  • Hypertension / physiopathology
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Protein Precursors
  • Retrospective Studies
  • Severity of Illness Index

Substances

  • Biomarkers
  • Peptide Fragments
  • Protein Precursors
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain