How pervasive are circadian oscillations?

V R Patel; K Eckel-Mahan; P Sassone-Corsi; P Baldi

doi:10.1016/j.tcb.2014.04.005

How pervasive are circadian oscillations?

Trends Cell Biol. 2014 Jun;24(6):329-31. doi: 10.1016/j.tcb.2014.04.005. Epub 2014 May 2.

Authors

V R Patel¹, K Eckel-Mahan², P Sassone-Corsi³, P Baldi⁴

Affiliations

¹ Department of Computer Science, University of California - Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA.
² Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA.
³ Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA.
⁴ Department of Computer Science, University of California - Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA. Electronic address: pfbaldi@ics.uci.edu.

Abstract

Circadian oscillations play a critical role in coordinating the physiology, homeostasis, and behavior of biological systems. Once thought to only be controlled by a master clock, recent high-throughput experiments suggest many genes and metabolites in a cell are potentially capable of circadian oscillations. Each cell can reprogram itself and select a relatively small fraction of this broad repertoire for circadian oscillations, as a result of genetic, environmental, and even diet changes.

Keywords: circadian metabolome; circadian rhythms; circadian transcriptome; clock; coupled oscillators; oscillatory patterns.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biological Clocks
Circadian Rhythm Signaling Peptides and Proteins / genetics
Circadian Rhythm*
Gene Expression Profiling
Gene Expression Regulation
Metabolome

Substances

Circadian Rhythm Signaling Peptides and Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding