Deciphering functions of branched ubiquitin chains

Jaime López-Mosqueda; Ivan Dikic

doi:10.1016/j.cell.2014.04.026

Deciphering functions of branched ubiquitin chains

Cell. 2014 May 8;157(4):767-9. doi: 10.1016/j.cell.2014.04.026.

Authors

Jaime López-Mosqueda¹, Ivan Dikic²

Affiliations

¹ Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
² Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address: dikic@biochem2.uni-frankfurt.de.

PMID: 24813601
DOI: 10.1016/j.cell.2014.04.026

Abstract

The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.

Publication types

Comment

MeSH terms

Anaphase-Promoting Complex-Cyclosome / metabolism*
Humans
Proteasome Endopeptidase Complex / metabolism*
Proteolysis*

Substances

Anaphase-Promoting Complex-Cyclosome
Proteasome Endopeptidase Complex