Abstract
We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bayes Theorem
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DNA Methylation / genetics*
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Genome / genetics*
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Genomics / methods
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Models, Genetic*
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Probability
Grants and funding
The authors would like to acknowledge the support provided by the Spanish Ministerio de Ciencia e Innovación (grant SAF2011-30391). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.