Equity in the receipt of oseltamivir in the United States during the H1N1 pandemic

Am J Public Health. 2014 Jun;104(6):1052-8. doi: 10.2105/AJPH.2013.301762. Epub 2014 Apr 17.

Abstract

Objectives: We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons.

Methods: In a cohort of individuals enrolled in pharmacy benefit plans, we used a multivariate logistic regression model to measure associations between subscriber characteristics and filling a prescription for oseltamivir during 3 flu seasons (October 2006-May 2007, October 2007-May 2008, and October 2008-May 2010). In 19 states with county-level influenza rates reported, we controlled for disease burden.

Results: Approximately 56 million subscribers throughout the United States were included in 1 or more study periods. During pandemic flu, beneficiaries in the highest income category had 97% greater odds of receiving oseltamivir than those in the lowest category (P < .001). After we controlled for disease burden, subscribers in the 2 highest income categories had 2.18 and 1.72 times the odds of receiving oseltamivir compared with those in the lowest category (P < .001 for both).

Conclusions: Income was a stronger predictor of oseltamivir receipt than prevalence of influenza. These findings corroborate concerns about equity of treatment in pandemics, and they call for improved approaches to distributing potentially life-saving treatments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antiviral Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Female
  • Healthcare Disparities / statistics & numerical data*
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / drug therapy*
  • Influenza, Human / epidemiology
  • Logistic Models
  • Male
  • Middle Aged
  • Oseltamivir / therapeutic use*
  • Pandemics / statistics & numerical data*
  • Sex Factors
  • United States / epidemiology
  • Young Adult

Substances

  • Antiviral Agents
  • Oseltamivir