Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

A E G Baird; S D Carter; J F Innes; W Ollier; A Short

doi:10.1111/age.12162

Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Anim Genet. 2014 Aug;45(4):542-9. doi: 10.1111/age.12162. Epub 2014 May 16.

Authors

A E G Baird¹, S D Carter, J F Innes, W Ollier, A Short

Affiliation

¹ Department of Infection Biology, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, Liverpool, L3 5RF, UK; CIGMR (Centre for Integrated Genomic Medical Research), Faculty of Medical and Human Sciences Manchester University, Manchester, M13 9PT, UK.

PMID: 24835129
DOI: 10.1111/age.12162

Abstract

Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.

Keywords: Newfoundlands; cranial cruciate ligament rupture; population stratification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anterior Cruciate Ligament Injuries*
Dog Diseases / epidemiology
Dog Diseases / genetics*
Dogs / injuries*
Genome-Wide Association Study / veterinary*
Polymorphism, Single Nucleotide*
Species Specificity

Abstract

Publication types

MeSH terms

Grants and funding