School-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants

J Pediatr. 2014 Aug;165(2):398-400.e3. doi: 10.1016/j.jpeds.2014.04.007. Epub 2014 May 14.

Abstract

In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the children exposed to MgSO4, although the differences were not significant.

Trial registration: ClinicalTrials.gov NCT00120588.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Cerebral Palsy / prevention & control*
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / prevention & control*
  • Magnesium Sulfate / adverse effects
  • Magnesium Sulfate / therapeutic use*
  • Male
  • Neuroprotective Agents / adverse effects
  • Neuroprotective Agents / therapeutic use*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Psychomotor Performance / drug effects
  • Psychomotor Performance / physiology
  • Surveys and Questionnaires
  • Treatment Outcome

Substances

  • Neuroprotective Agents
  • Magnesium Sulfate

Associated data

  • ClinicalTrials.gov/NCT00120588