Epigenetic inheritance of metabolic state

Abstract

As the incidence of complex metabolic disease increases in developed countries, so too does the need to understand the causes and risk factors for these disorders. In addition to the well-known contribution of genetics and environment to metabolic dysfunction, many studies have demonstrated that a significant degree of non-genetic heritable risk can be transmitted from parents to offspring over multiple generations. Understanding the mechanisms by which this occurs could change how we study and treat complex metabolic disorders. In this review, we summarize recent advances in this field utilizing Drosophila, mice, and humans, and propose potential molecular mechanisms that underlie the transgenerational inheritance of metabolic state.