Nitric oxide and histone acetylation-shaping craniofacial development

Libera Berghella; Pier Lorenzo Puri

doi:10.1016/j.chembiol.2014.05.002

Nitric oxide and histone acetylation-shaping craniofacial development

Chem Biol. 2014 May 22;21(5):565-6. doi: 10.1016/j.chembiol.2014.05.002.

Authors

Libera Berghella¹, Pier Lorenzo Puri²

Affiliations

¹ Epigenetics & Regenerative Medicine, IRCCS Fondazione Santa Lucia, 00142 Rome, Italy.
² Epigenetics & Regenerative Medicine, IRCCS Fondazione Santa Lucia, 00142 Rome, Italy; Development, Aging and Regeneration (DAR) Program, Sanford-Burnham Medical Research Institute, Sanford Children's Health Research Center, La Jolla, CA 92037, USA. Electronic address: lpuri@sanfordburnham.org.

Abstract

Previous work linked nitric oxide (NO) signaling to histone deacetelyases (HDACs) in the control of tissue homeostasis and suggested that deregulation of this signaling contributes to human diseases. In the previous issue of Chemistry & Biology, Kong and colleagues showed that coordinated NO signaling and histone acetylation are required for proper cranial neural crest development and craniofacial morphogenesis and suggested that alterations of NO/acetylation network can contribute to the pathogenesis of craniofacial malformations.

Publication types

Comment

MeSH terms

Animals
Histones / metabolism*
Morphogenesis*
Neural Crest / embryology*
Neural Crest / metabolism*
Nitric Oxide / metabolism*
Zebrafish / embryology*
Zebrafish / metabolism*

Substances

Histones
Nitric Oxide

Abstract

Publication types

MeSH terms

Substances

Grants and funding