FDG PET/CT depicts cutaneous plasmocytoma

Clin Nucl Med. 2014 Oct;39(10):910-1. doi: 10.1097/RLU.0000000000000478.

Abstract

A 63-year-old man with a 1-year course of IgA-λ multiple myeloma (MM) and a history of autologous stem cell transplantation presented with multiple nontender, nodular violaceous skin lesions that were located predominantly on his trunk. Diagnostic workup using F-FDG PET/CT revealed disseminated disease including highly hypermetabolic (sub)cutaneous lesions, consistent with active manifestations of MM. Histopathology confirmed monoclonal, λ-restricted plasma cell infiltrates with a high proliferation index (Ki-67) of about 80%. Cutaneous manifestation of MM is an uncommon observation in clinical practice portending poor prognosis.

Publication types

  • Case Reports

MeSH terms

  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Multimodal Imaging*
  • Multiple Myeloma / diagnostic imaging*
  • Multiple Myeloma / pathology
  • Neoplasm Invasiveness / diagnostic imaging
  • Neoplasm Invasiveness / pathology
  • Plasmacytoma / diagnostic imaging*
  • Plasmacytoma / pathology
  • Positron-Emission Tomography*
  • Radiopharmaceuticals
  • Skin / diagnostic imaging*
  • Skin / pathology
  • Tomography, X-Ray Computed*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18