Malignant rhabdoid tumor of the liver presented with initial tumor rupture

Cancer Genet. 2014 Sep;207(9):412-4. doi: 10.1016/j.cancergen.2014.04.006. Epub 2014 Apr 21.

Abstract

Malignant rhabdoid tumor (MRT) of the liver is a rare, highly aggressive tumor of early childhood. We report a 6-month-old boy who was diagnosed with MRT of the liver and presented with spontaneous tumor rupture. The patient underwent intensified chemotherapy and a radical surgical procedure. Twenty four months from the time of the diagnosis, he is alive without evidence of disease. This is the second report of prolonged survival after initial rupture of hepatic MRT.

Keywords: Malignant rhabdoid tumor; chemotherapy; liver; tumor rupture.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Chromosomal Proteins, Non-Histone / genetics
  • DNA-Binding Proteins / genetics
  • Humans
  • Infant
  • Liver / pathology
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology*
  • Male
  • Rhabdoid Tumor / drug therapy*
  • Rhabdoid Tumor / genetics
  • Rhabdoid Tumor / pathology*
  • Rupture
  • SMARCB1 Protein
  • Transcription Factors / genetics

Substances

  • Antineoplastic Agents
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • SMARCB1 Protein
  • SMARCB1 protein, human
  • Transcription Factors