Differentiation between free and bound leptin in depressed patients

Maria Strauss; Roland Mergl; Juergen Kratzsch; Mathias Brügel; Erik Strauss; Ulrich Hegerl; Peter Schoenknecht

doi:10.1016/j.psychres.2014.05.030

Differentiation between free and bound leptin in depressed patients

Psychiatry Res. 2014 Oct 30;219(2):397-9. doi: 10.1016/j.psychres.2014.05.030. Epub 2014 Jun 2.

Authors

Maria Strauss¹, Roland Mergl², Juergen Kratzsch³, Mathias Brügel⁴, Erik Strauss⁵, Ulrich Hegerl², Peter Schoenknecht²

Affiliations

¹ Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany. Electronic address: maria.strauss@medizin.uni-leipzig.de.
² Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany.
³ Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.
⁴ Institute of Clinical Chemistry, Ludwig-Maximilians-University Munich, Germany.
⁵ Medical Practice for Neurology, Psychiatry and Psychotherapy, Kopfzentrum Leipzig(®), Germany.

PMID: 24930579
DOI: 10.1016/j.psychres.2014.05.030

Abstract

The relationship between leptin and affective disorders is still unknown. We measured free and bound leptin in 13 drug naïve subjects. Leptin did not significantly differ between patients and controls. As part of future studies, it also appears useful to distinguish between free and bound leptin.

Keywords: Affective disorders; Cerebrospinal fluid; Soluble leptin receptor.

MeSH terms

Adult
Depressive Disorder, Major / blood
Depressive Disorder, Major / cerebrospinal fluid
Depressive Disorder, Major / metabolism*
Female
Humans
Leptin / blood
Leptin / cerebrospinal fluid
Leptin / metabolism*
Male
Middle Aged
Receptors, Leptin / metabolism*
Young Adult

Substances

Leptin
Receptors, Leptin