Does Teno Torque Virus Induce Autoimmunity After Hematopoietic Stem Cell Transplantation? A Case Report

J Pediatr Hematol Oncol. 2015 Apr;37(3):e194-7. doi: 10.1097/MPH.0000000000000194.

Abstract

Teno Torque virus, member of the family of Anelloviridae, has been associated with many autoimmune diseases such as idiopathic hepatitis, systemic lupus erythematosus, and multiple sclerosis. Its viral load tends to be higher in the bone marrow and in tissues with high turnover rate. We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. Extremely high-cytokine IP-10 and eotaxin levels were found in her sera, and serological tests and RT-PCR for viruses showed positive results exclusively for Teno Torque virus.

Publication types

  • Case Reports

MeSH terms

  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / pathology
  • Autoimmunity / immunology*
  • DNA Virus Infections / immunology
  • DNA Virus Infections / pathology
  • DNA Virus Infections / virology*
  • DNA, Viral / genetics
  • Dermatitis, Atopic / drug therapy
  • Dermatitis, Atopic / etiology*
  • Dermatitis, Atopic / pathology
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hepatitis / drug therapy
  • Hepatitis / etiology*
  • Hepatitis / pathology
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / immunology*
  • Leukemia, Myeloid, Acute / therapy
  • Leukemia, Myeloid, Acute / virology
  • Prognosis
  • Torque teno virus / genetics
  • Torque teno virus / isolation & purification
  • Torque teno virus / pathogenicity*
  • Viral Load

Substances

  • DNA, Viral