The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

Affiliations

• ¹ Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
• ² European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
• ³ Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel.
• ⁴ Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California, San Diego, La Jolla, CA, USA.
• ⁵ Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
• ⁶ Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁷ Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
• ⁸ Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
• ⁹ Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
• ¹⁰ Department of Human Genetics, University of Heidelberg, Germany.
• ¹¹ Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
• ¹² Children's Hospital, University Hospital Tübingen, Germany.
• ¹³ Department of Oncology, University Children's Hospital Zurich, Switzerland.
• ¹⁴ European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.
• ¹⁵ Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.