Abstract
Disseminated intravascular coagulation (DIC) is a complex abnormality of hemostasis with dramatic consequences and long described as associated with tumors. Yet the diagnosis and management of paraneoplastic DIC are poorly defined. The purpose of this paper is to review DIC associated with solid tumors, at the pathophysiological and therapeutic levels in particular. We also report data from a recent retrospective series of patients with DIC in the context of a solid tumor, to illustrate the epidemiological, clinical and prognostic.
Keywords:
cancer; disseminated intravascular coagulation; paranéoplastic syndrom.
MeSH terms
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Anticoagulants / therapeutic use
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Blood Coagulation / physiology
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Coagulants / therapeutic use
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Disseminated Intravascular Coagulation* / blood
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Disseminated Intravascular Coagulation* / diagnosis
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Disseminated Intravascular Coagulation* / epidemiology
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Disseminated Intravascular Coagulation* / etiology
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Disseminated Intravascular Coagulation* / physiopathology
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Disseminated Intravascular Coagulation* / therapy
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Factor VIIa / therapeutic use
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Humans
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Neoplasms / blood*
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Neoplasms / pathology
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Neoplasms / therapy
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Paraneoplastic Syndromes* / blood
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Paraneoplastic Syndromes* / diagnosis
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Paraneoplastic Syndromes* / etiology
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Paraneoplastic Syndromes* / physiopathology
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Paraneoplastic Syndromes* / therapy
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Platelet Transfusion
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Prognosis
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Recombinant Proteins / therapeutic use
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Risk Factors
Substances
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Anticoagulants
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Coagulants
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Recombinant Proteins
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recombinant FVIIa
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Factor VIIa