Copper-catalyzed intermolecular trifluoromethylarylation of alkenes: mutual activation of arylboronic acid and CF3+ reagent

J Am Chem Soc. 2014 Jul 23;136(29):10202-5. doi: 10.1021/ja504458j. Epub 2014 Jul 8.

Abstract

A novel copper-catalyzed intermolecular trifluoromethylarylation of alkenes is developed using less active ether-type Togni's reagent under mild reaction conditions. Various alkenes and diverse arylboronic acids are compatible with these conditions. Preliminary mechanistic studies reveal that a mutual activation process between arylboronic acid and CF3(+) reagent is essential. In addition, the reaction might involve a rate-determining transmetalation, and the final aryl C-C bond is derived from reductive elimination of the aryl(alkyl)Cu(III) intermediate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Chlorofluorocarbons, Methane / chemistry*
  • Copper / chemistry*
  • Hydrocarbons, Cyclic* / chemical synthesis
  • Hydrocarbons, Cyclic* / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkenes
  • Boronic Acids
  • Chlorofluorocarbons, Methane
  • Hydrocarbons, Cyclic
  • Copper
  • fluoroform