Effect of 12-month intervention with lipid-based nutrient supplements on physical activity of 18-month-old Malawian children: a randomised, controlled trial

Eur J Clin Nutr. 2015 Feb;69(2):173-8. doi: 10.1038/ejcn.2014.138. Epub 2014 Jul 16.

Abstract

Background/objectives: This study measured the effects of dietary supplementation with lipid-based nutrient supplements (LNSs) on 18-month-old children's physical activity.

Subjects/methods: In a randomised, controlled, outcome-assessor blinded trial 1932 six-month-old children from Malawi received one of five interventions daily from 6-18 months of age: 10-g milk-LNS, 20-g milk-LNS, 20-g non-milk-LNS, 40-g milk-LNS or 40-g non-milk-LNS, or received no intervention in the same period (control). The control group received delayed intervention with corn-soy blend from 18-30 months. Physical activity was measured over 1 week by ActiGraph GT3X+ accelerometer at 18 months. Main outcome was mean vector magnitude accelerometer counts/15 s. Analyses were restricted to children with valid accelerometer data on at least 4 days with minimum 6 h of wearing time per day.

Results: Of the 1435 children recruited to this substudy, 1053 provided sufficient data for analysis. The mean (s.d.) vector magnitude accelerometer counts in the total sample were 307 (64). The difference (95% CI) in mean accelerometer counts, compared with the control group, was 8 (-6 to 21, P=0.258) in 10-g milk-LNS, 3 (-11 to 17, P=0.715) in 20-g milk-LNS, 5 (-8 to 19, P=0.445) in 20-g non-milk-LNS, 10 (-3 to 23, P=0.148) in 40-g milk-LNS and 2 (-12 to 16, P=0.760) in 40-g non-milk-LNS groups.

Conclusions: Provision of 10-40 g doses of LNS daily for 12 months did not increase physical activity of Malawian toddlers.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actigraphy
  • Animals
  • Dietary Fats / pharmacology*
  • Dietary Supplements*
  • Energy Intake / physiology*
  • Female
  • Food, Fortified*
  • Humans
  • Infant
  • Infant Food*
  • Infant Nutritional Physiological Phenomena*
  • Lipids / pharmacology
  • Malawi
  • Male
  • Malnutrition / prevention & control
  • Milk
  • Motor Activity*
  • Single-Blind Method

Substances

  • Dietary Fats
  • Lipids