Abstract
Changes in the hair cycle underlie age-related alopecia, but the causative mechanisms have remained unclear. Chen et al. point to an imbalance between stem cell-activating and -inhibitory signals as the key determinant of age-related regenerative decline. Further, they identify a secreted protein, follistatin, that may be able to shift the balance toward renewal.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Aging / physiology*
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Animals
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Follistatin / physiology*
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Hair Follicle / physiology*
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Intercellular Signaling Peptides and Proteins / physiology*
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Proto-Oncogene Proteins / physiology*
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Regeneration / physiology*
Substances
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Dkk1 protein, mouse
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Follistatin
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Intercellular Signaling Peptides and Proteins
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Proto-Oncogene Proteins
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Sfrp4 protein, mouse