Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo

Rui André Saraiva Raposo; Mohamed Abdel-Mohsen; Xutao Deng; Frederick M Hecht; Christopher D Pilcher; Satish K Pillai; Douglas F Nixon

doi:10.1128/JVI.01771-14

Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo

J Virol. 2014 Oct;88(19):11624-9. doi: 10.1128/JVI.01771-14. Epub 2014 Jul 16.

Authors

Rui André Saraiva Raposo¹, Mohamed Abdel-Mohsen², Xutao Deng³, Frederick M Hecht⁴, Christopher D Pilcher⁴, Satish K Pillai⁵, Douglas F Nixon⁶

Affiliations

¹ Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA araposo@gwu.edu.
² Department of Medicine, University of California San Francisco, San Francisco, California, USA Blood Systems Research Institute, San Francisco, California, USA.
³ Blood Systems Research Institute, San Francisco, California, USA.
⁴ UCSF Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
⁵ Blood Systems Research Institute, San Francisco, California, USA Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
⁶ Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA.

Abstract

In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and viral load. Our data are among the first to demonstrate the dynamic nature of host restriction factors in vivo over time.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / virology
Gene Expression Profiling
Gene Expression Regulation*
HIV Infections / genetics*
HIV Infections / immunology
HIV Infections / metabolism
HIV Infections / virology
HIV-1 / physiology*
Host-Pathogen Interactions
Humans
Longitudinal Studies
Lymphocyte Activation
Male
RNA, Viral / genetics*
RNA, Viral / metabolism
Repressor Proteins / genetics*
Repressor Proteins / metabolism
Viral Load

Substances

RNA, Viral
Repressor Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding