MicroRNA-mediated repression combats depression

Mary P Heyer; Paul J Kenny

doi:10.1016/j.neuron.2014.07.008

MicroRNA-mediated repression combats depression

Neuron. 2014 Jul 16;83(2):253-254. doi: 10.1016/j.neuron.2014.07.008.

Authors

Mary P Heyer¹, Paul J Kenny²

Affiliations

¹ Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
² Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.

PMID: 25033172
DOI: 10.1016/j.neuron.2014.07.008

Abstract

Precisely how SSRIs induce long-term modifications in serotonin transmission to elicit their antidepressant actions is unclear. In this issue of Neuron, Issler et al. (2014) identify a key role for microRNA-135a [corrected] in the raphe nuclei in the molecular mechanisms underlying the therapeutic actions of SSRIs.

Publication types

Comment

MeSH terms

Animals
Antidepressive Agents / therapeutic use*
Brain / drug effects*
Depression / drug therapy*
MicroRNAs / genetics*
Resilience, Psychological*
Serotonin / metabolism*
Stress, Psychological / genetics*

Substances

Antidepressive Agents
MicroRNAs
Mirn135 microRNA, mouse
Serotonin