Proteinticle/gold core/shell nanoparticles for targeted cancer therapy without nanotoxicity

Adv Mater. 2014 Oct 8;26(37):6436-41. doi: 10.1002/adma.201401499. Epub 2014 Jul 8.

Abstract

PGCS-NPs (40 nm) with excellent photo-thermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

Keywords: core/shell; gold nanoparticle; nanotoxicity; photothermal therapy; proteinticle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal, Humanized / immunology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cetuximab
  • ErbB Receptors / immunology
  • ErbB Receptors / metabolism
  • Gold / chemistry*
  • Humans
  • Infrared Rays
  • Liver / pathology
  • Mice
  • Mice, Nude
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Particle Size
  • Peptides / chemistry*
  • Peptides / metabolism
  • Photochemotherapy
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / therapeutic use
  • Photosensitizing Agents / toxicity
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / metabolism
  • Transplantation, Heterologous

Substances

  • Antibodies, Monoclonal, Humanized
  • Peptides
  • Photosensitizing Agents
  • Recombinant Fusion Proteins
  • Gold
  • ErbB Receptors
  • Cetuximab