This paper presents a configurable CMOS integrated circuit front-end for the recording of a wide range of biopotentials (ExG). The system offers a choice between a single-differential or double-differential recording channel topology, wide continuously adjustable gain range (37-66 dB), selectable CMOS or BJT input stages, offset compensation, differential and buffered single-ended voltage output. Measured results from a prototype manufactured in 0.35 μm CMOS technology are presented. Practical recording examples of the electrocardiogram (ECG) and electromyogram (EMG) confirm its operation. The chip consumes between 110 and 324 μW depending on configuration, occupies a core area of 0.16 mm(2), achieves a CMRR > 97 dB , and 21 nV/√Hz input-referred noise. The chip is suited for combination with a microcontroller in long-term wearable physiological sensing applications.