1 Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK sb930@cam.ac.uk.
2 Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
3 Healthways International, Franklin, TN 37067, USA.
4 Bristol Surgical Trials Center, School of Social & Community Medicine, University of Bristol Canynge Hall, Bristol BS8 2PS, UK University Hospitals Bristol, NHS Foundation Trust, Bristol BS1 3NU, UK.