Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism

Mov Disord. 2014 Nov;29(13):1684-7. doi: 10.1002/mds.26019. Epub 2014 Sep 3.

Abstract

Background: Families of Dutch-German-Russian Mennonite descent with multi-incident parkinsonism have been identified as harboring a pathogenic DNAJC13 p.N855S mutation and are awaiting clinical and pathophysiological characterization.

Methods: Family members were examined clinically longitudinally, and 5 underwent dopaminergic PET imaging. Four family members came to autopsy.

Results: Of the 16 symptomatic DNAJC13 mutation carriers, 12 had clinically definite, 3 probable, and 1 possible Parkinson's disease (PD). Symptoms included bradykinesia, tremor, rigidity, and postural instability, with a mean onset of 63 years (range, 40-85) and slow progression. Eight of ten subjects who required treatment had a good levodopa response; motor complications and nonmotor symptoms were observed. Dopaminergic PET imaging revealed rostrocaudal striatal deficits typical for idiopathic PD in established disease and subtle abnormalities in incipient disease. Pathological examinations revealed Lewy body pathology.

Conclusion: PD associated with a DNAJC13 p.N855S mutation presents as late-onset, often slowly progressive, usually dopamine-responsive typical PD.

Keywords: DNAJC13; Lewy Body Pathology; Mennonite; Parkinson's disease (PD); Positron Emission Tomography (PET); familial PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain / diagnostic imaging*
  • Brain / drug effects
  • Carbon Isotopes / pharmacokinetics
  • Dopamine Agents / pharmacokinetics
  • Family Health
  • Fluorodeoxyglucose F18
  • Humans
  • Levodopa / pharmacokinetics
  • Middle Aged
  • Molecular Chaperones / genetics*
  • Mutation / genetics*
  • Parkinsonian Disorders / diagnosis*
  • Parkinsonian Disorders / genetics*
  • Positron-Emission Tomography*
  • Tetrabenazine / analogs & derivatives
  • Tetrabenazine / pharmacokinetics

Substances

  • Carbon Isotopes
  • DNAJC13 protein, human
  • Dopamine Agents
  • Molecular Chaperones
  • Fluorodeoxyglucose F18
  • dihydrotetrabenazine
  • Levodopa
  • Tetrabenazine