Neurotologic and functional MRI findings in a patient with bilateral profound deafness having Brown-Vialetto-Van Leare syndrome

Otol Neurotol. 2014 Oct;35(9):1495-500. doi: 10.1097/MAO.0000000000000572.

Abstract

Introduction: We report the first findings of functional magnetic resonance imaging of the auditory cortex in a young woman with a bilateral cochleovestibular deficit as first manifestation of Brown-Vialetto-Van Leare syndrome. The patient had no open speech discrimination, even with hearing aids, and is depending on lip reading for communication.

Methods: To evaluate the possible efficiency of a cochlear implantation, we investigated hemodynamic responses within the central auditory pathways using an auditory functional magnetic resonance imaging paradigm.

Results: Blood oxygen level-dependent correlates were detected bilaterally along the auditory pathways after exposure to intermittent clicking tone stimulation at 2 kHz.

Conclusion: These results suggest integrity of the central auditory pathways and represent a positive argument to propose a cochlear implantation with the aim to restore hearing.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Auditory Cortex / physiopathology*
  • Auditory Pathways / physiopathology
  • Bulbar Palsy, Progressive / diagnosis*
  • Bulbar Palsy, Progressive / physiopathology*
  • Cochlear Implantation / methods
  • Female
  • Hearing Loss, Sensorineural / diagnosis*
  • Hearing Loss, Sensorineural / physiopathology*
  • Hearing Tests
  • Humans
  • Magnetic Resonance Imaging
  • Speech Perception

Supplementary concepts

  • Brown-Vialetto-Van Laere syndrome