Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

Chem Commun (Camb). 2014 Oct 28;50(84):12742-5. doi: 10.1039/c4cc06343k.

Abstract

The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boranes / chemistry
  • Catalysis
  • Cell Survival / drug effects
  • Click Chemistry
  • HCT116 Cells
  • Humans
  • Nanoparticles / chemistry*
  • Nanoparticles / toxicity
  • Polyethylene Glycols / chemistry
  • Polysaccharides / chemical synthesis
  • Polysaccharides / chemistry*

Substances

  • Boranes
  • Polysaccharides
  • Polyethylene Glycols
  • boron trifluoride etherate