Internal radiation dosimetry of orally administered radiotracers for the assessment of gastrointestinal motility

Appl Radiat Isot. 2014 Dec:94:216-220. doi: 10.1016/j.apradiso.2014.08.009. Epub 2014 Aug 23.

Abstract

Radionuclide imaging using (111)In, (99m)Tc and (153)Sm is commonly undertaken for the clinical investigation of gastric emptying, intestinal motility and whole gut transit. However the documented evidence concerning internal radiation dosimetry for such studies is not readily available. This communication documents the internal radiation dosimetry for whole gastrointestinal transit studies using (111)In, (99m)Tc and (153)Sm labeled formulations. The findings were compared to the diagnostic reference levels recommended by the United Kingdom Administration of Radioactive Substances Advisory Committee, for gastrointestinal transit studies.

Keywords: Gastrointestinal transit; In-111; Medical internal radiation dosimetry (MIRD); Oral administration of radionuclides; Sm-153.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Computer Simulation
  • Gastrointestinal Contents / diagnostic imaging*
  • Gastrointestinal Motility / physiology*
  • Gastrointestinal Tract / diagnostic imaging*
  • Gastrointestinal Tract / metabolism*
  • Humans
  • Metabolic Clearance Rate
  • Models, Biological*
  • Radiation Dosage
  • Radiometry / methods*
  • Radionuclide Imaging
  • Radiopharmaceuticals / administration & dosage
  • Radiopharmaceuticals / pharmacokinetics*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Radiopharmaceuticals