Extramammary Paget disease: a report of 10 cases

Actas Dermosifiliogr. 2015 Jan-Feb;106(1):e1-5. doi: 10.1016/j.ad.2014.05.008. Epub 2014 Sep 26.
[Article in English, Spanish]

Abstract

Extramammary Paget disease (EMPD) is a very rare form of intraepithelial adenocarcinoma. We report the cases of EMPD diagnosed in a referral hospital over a 5-year period from 2009 to 2013. Ten cases of EMPD were diagnosed in 4 men and 6 women aged between 50 and 79 years. Erroneous clinical diagnoses led to diagnostic delays of 1 to 5 years in all cases. Six patients had in situ lesions and dermal invasion was observed in the other 4 cases. Four patients had a second neoplasm and 2 of the patients with invasive EMPD died. Because EMPD is rare and its clinical presentation is nonspecific, a high degree of clinical suspicion is required to avoid delays in diagnosis and treatment.

Keywords: Adenocarcinoma; Enfermedad de Paget extramamaria; Extramammary Paget disease; Rare tumor; Tumor raro.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnostic Errors
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Paget Disease, Extramammary* / diagnosis
  • Paget Disease, Extramammary* / pathology