Quantification of epidermal growth factor in human breast cyst fluids: correlation with dehydroepiandrosterone-sulphate and electrolyte concentrations

Int J Cancer. 1989 Aug 15;44(2):229-32. doi: 10.1002/ijc.2910440207.

Abstract

Epidermal growth factor (EGF), dehydroepiandrosterone (DHA)-sulphate and [Na+] and [K+] were assayed in 78 cyst fluids from patients with a palpable breast cyst. Epidermal growth factor was detected in all but 2 cysts, the mean value +/- SEM being 506.2 +/- 39.3 ng/ml, with a range of 0-1,599 ng/ml. When the cyst fluids were sub-divided according to their [Na+]:[K+] ratio, group A cyst fluids ( [Na+]:[K+] less than 3) had a significantly higher (p less than 0.001) level of EGF than group B cyst fluids ([Na+]:[K+] greater than 3). Furthermore, the relationship between EGF and [Na+] and [K+] and between EGF and DHA-sulphate seemed to differ between the 2 cyst types and each cyst type was therefore analyzed separately.

MeSH terms

  • Aged
  • Dehydroepiandrosterone / analogs & derivatives*
  • Dehydroepiandrosterone / analysis
  • Dehydroepiandrosterone Sulfate
  • Electrolytes / analysis*
  • Epidermal Growth Factor / analysis*
  • Female
  • Fibrocystic Breast Disease / analysis*
  • Humans
  • Middle Aged
  • Proteins / analysis
  • Radioimmunoassay

Substances

  • Electrolytes
  • Proteins
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate
  • Epidermal Growth Factor