[70]Fullerenes assist the formation of phospholipid bicelles at low lipid concentrations

Atsushi Ikeda; Kazuya Kiguchi; Tomohiro Hida; Kazuma Yasuhara; Kazuyuki Nobusawa; Motofusa Akiyama; Wataru Shinoda

doi:10.1021/la503732q

[70]Fullerenes assist the formation of phospholipid bicelles at low lipid concentrations

Langmuir. 2014 Oct 21;30(41):12315-20. doi: 10.1021/la503732q. Epub 2014 Oct 10.

Authors

Atsushi Ikeda¹, Kazuya Kiguchi, Tomohiro Hida, Kazuma Yasuhara, Kazuyuki Nobusawa, Motofusa Akiyama, Wataru Shinoda

Affiliation

¹ Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University , Higashi-Hiroshima 739-8527, Japan.

PMID: 25275703
DOI: 10.1021/la503732q

Abstract

The incorporation of neutral [70]fullerenes (C70) led to bicelle formation in a relatively low lipid concentration range from neutral lipid mixtures (DMPC/DHPC). Furthermore, C70 addition resulted in the formation of large bicelles with a radius of ca. 100 nm, in contrast to C70-free bicelles that were formed from anionic lipid mixtures (DMPC/DHPC/DMPG). The stabilization of these bicelles was attributed to C70 incorporation into the membranes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fullerenes / chemistry*
Molecular Dynamics Simulation
Molecular Structure
Particle Size
Phospholipids / analysis*
Phospholipids / chemistry*
Surface Properties

Substances

Fullerenes
Phospholipids
fullerene C70