PRDM1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour

Oral Dis. 2015 May;21(4):432-6. doi: 10.1111/odi.12294. Epub 2015 Jan 12.

Abstract

Objective: To determine the role of PRDM1, a key molecule for modulating the immune cells, in Warthin tumour (WT) pathogenesis.

Subjects and methods: Forty paraffin-embedded parotid tissues of patients (mean age: 62.08 ± 11.90) with WT were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The PRDM1 expression was investigated in a cohort of WT by immunohistochemistry.

Results: PRDM1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, PRDM1 expression rates between WT glandular epithelial cells (40/40 cases) and the tumour-adjacent tissues (0/9 cases), and WT germinal centres (0/34 cases) and tonsil tissues (10/10 cases) were significantly different (P < 0.001), respectively.

Conclusions: The PRDM1 expression appeared to play an essential role in WT pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.

Keywords: PRDM1; Warthin tumour; ectopic lymphoid tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenolymphoma / metabolism*
  • Adult
  • Aged
  • Aged, 80 and over
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Female
  • Germinal Center / pathology
  • Humans
  • Immunohistochemistry
  • Lymphoid Tissue / metabolism*
  • Male
  • Middle Aged
  • Parotid Gland / pathology
  • Parotid Neoplasms / metabolism*
  • Positive Regulatory Domain I-Binding Factor 1
  • Repressor Proteins / analysis
  • Repressor Proteins / biosynthesis*

Substances

  • Repressor Proteins
  • PRDM1 protein, human
  • Positive Regulatory Domain I-Binding Factor 1