Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma

Leuk Res. 2014 Nov;38(11):1374-7. doi: 10.1016/j.leukres.2014.09.007. Epub 2014 Sep 22.

Abstract

Diffuse Large B-cell Lymphoma (DLBCL) is the most common form of Non-Hodgkin lymphoma characterized by clinical and biological heterogeneity attributable both to the tumor cells and the complex tumor-microenvironment surrounding them. Tumor-associated macrophages (TAMs) and mast cells are two major components of the tumor inflammatory infiltrate with a definite role in enhancing tumor angiogenesis. In this study, we have investigated CD68 and tryptase expression and their relationship with microvascular density (MVD) in chemo-resistant and chemosensitive patients affected by DLBCL. CD68 and tryptase expression as well as MVD were increased in chemo-resistant patients when compared with chemosensitive patients. Tryptase expression showed a positive correlation with MVD, supporting a role for mast cell in DLBCL tumor angiogenesis, while CD68 correlation with MVD was not significant, indicating a different role for TAMs than angiogenesis in DLBCL.

Keywords: Diffuse Large B-Cell Lymphoma; Macrophages; Mast cells; Microvascular density.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / immunology*
  • Antigens, Differentiation, Myelomonocytic / immunology*
  • Female
  • Humans
  • Lymphoma, Large B-Cell, Diffuse* / enzymology
  • Lymphoma, Large B-Cell, Diffuse* / immunology
  • Lymphoma, Large B-Cell, Diffuse* / pathology
  • Male
  • Microvessels / pathology*
  • Middle Aged
  • Retrospective Studies
  • Tryptases / metabolism*
  • Tumor Microenvironment

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human
  • Tryptases