Periostin: a new extracellular regulator of obesity-induced hepatosteatosis

Tiantian Wu; Shasha Wu; Gaoliang Ouyang

doi:10.1016/j.cmet.2014.09.005

Periostin: a new extracellular regulator of obesity-induced hepatosteatosis

Cell Metab. 2014 Oct 7;20(4):562-4. doi: 10.1016/j.cmet.2014.09.005.

Authors

Tiantian Wu¹, Shasha Wu¹, Gaoliang Ouyang²

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
² State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address: oygldz@xmu.edu.cn.

PMID: 25295785
DOI: 10.1016/j.cmet.2014.09.005

Abstract

Periostin is a crucial extracellular remodeling factor in the inflammatory and tumor microenvironments, but its function in nonalcoholic fatty liver disease remains unclear. Lu et al. (2014) now demonstrate that periostin is a critical player in the regulation of hepatic triglyceride homeostasis and the development of obesity-induced hepatosteatosis.

Publication types

Comment

MeSH terms

Animals
Cell Adhesion Molecules / metabolism*
Fatty Liver / etiology*
Fatty Liver / metabolism*
Female
Humans
Hypertriglyceridemia / etiology*
Hypertriglyceridemia / metabolism*
Male
PPAR alpha / metabolism*

Substances

Cell Adhesion Molecules
PPAR alpha