An enantioselective approach to the preparation of chiral sulfones by Ir-catalyzed asymmetric hydrogenation

J Am Chem Soc. 2014 Nov 26;136(47):16557-62. doi: 10.1021/ja5079877. Epub 2014 Nov 12.

Abstract

Several chiral sulfonyl compounds were prepared using the iridium catalyzed asymmetric hydrogenation reaction. Vinylic, allylic and homoallylic sulfone substitutions were investigated, and high enantioselectivity is maintained regardless of the location of the olefin with respect to the sulfone. Impressive stereoselectivity was obtained for dialkyl substitutions, which typically are challenging substrates in the hydrogenation. As expected, the more bulky Z-substrates were hydrogenated slower than the corresponding E isomers, and in slightly lower enantioselectivity.