The motor function measure to study limitation of activity in children and adults with Charcot-Marie-Tooth disease

Abstract

Objective: To study the applicability and responsiveness of the motor function measure (total score and sub-scores D1, D2 and D3) in patients with Charcot-Marie-Tooth disease.

Patients and methods: Two hundred and thirty-three patients aged 4-86 years were included in the descriptive study. Scores and sub-scores were analyzed by age and by disease subtypes. Sensitivity to change (responsiveness) was estimated in patients having had at least two evaluations with at least six months between the first and the second.

Results: Motor function measure scores decrease with age, especially sub-scores D1 and D3. There were no significant differences between the scores according to type of Charcot-Marie-Tooth disease. The scores were significantly higher for ambulatory than for non-ambulatory patients. Significant responsiveness was demonstrated only in type 2 Charcot-Marie-Tooth disease.

Discussion/conclusions: Our results suggest that, especially for D1 and D3 sub-scores, the motor function measure is a reliable and valid outcome measure that can be usefully applied in longitudinal follow-up. Studies of longer duration could demonstrate its responsiveness in other Charcot-Marie-Tooth disease subtypes.

Keywords: Activity limitation; Charcot-Marie-Tooth disease; Functional scale; Limitation d’activités; Maladie de Charcot-Marie-Tooth; Maladie neuromusculaire; Mesure de Fonction Motrice; Motor Function Measure; Neuromuscular disease; Échelle fonctionnelle.