Organocatalytic diversity-oriented asymmetric synthesis of tricyclic chroman derivatives

J Org Chem. 2014 Nov 21;79(22):10772-85. doi: 10.1021/jo501560m. Epub 2014 Oct 30.

Abstract

The tandem oxo-Michael-IED/HDA and oxo-Michael-IED/HDA-Michael-Aldol condensation transformations between (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with enals have been developed in the presence of (S)-diphenylprolinol trimethylsilyl ether as an organocatalyst. Two types of tricyclic chroman derivatives were, respectively, obtained, by adjusting the reactant ratio and reaction temperature, in good yields (up to 96%) with excellent enantioselectivities (up to >99%) and good diastereoselectivities (up to >30/1). It should be noted that the divergent chiral chroman derivatives were obtained by successive reaction of (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with two different enal substrates in highly catalytic results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Butyrates / chemistry*
  • Catalysis
  • Chromans / chemical synthesis*
  • Chromans / chemistry
  • Ethers / chemistry*
  • Molecular Structure
  • Pyrrolidines / chemistry*
  • Stereoisomerism
  • Trimethylsilyl Compounds / chemistry*

Substances

  • Butyrates
  • Chromans
  • Ethers
  • Pyrrolidines
  • Trimethylsilyl Compounds
  • diphenylprolinol
  • diphenylprolinol trimethylsilyl ether