Delayed development of neural language organization in very preterm born children

Dev Neuropsychol. 2014;39(7):529-42. doi: 10.1080/87565641.2014.959173.

Abstract

This study investigates neural language organization in very preterm born children compared to control children and examines the relationship between language organization, age, and language performance. Fifty-six preterms and 38 controls (7-12 y) completed a functional magnetic resonance imaging language task. Lateralization and signal change were computed for language-relevant brain regions. Younger preterms showed a bilateral language network whereas older preterms revealed left-sided language organization. No age-related differences in language organization were observed in controls. Results indicate that preterms maintain atypical bilateral language organization longer than term born controls. This might reflect a delay of neural language organization due to very premature birth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / growth & development
  • Brain / physiology*
  • Brain Mapping
  • Case-Control Studies
  • Child
  • Developmental Disabilities
  • Female
  • Humans
  • Infant, Extremely Low Birth Weight
  • Infant, Extremely Premature / physiology*
  • Infant, Newborn
  • Language Development*
  • Language*
  • Magnetic Resonance Imaging*
  • Male
  • Neural Pathways / pathology*
  • Pregnancy
  • Premature Birth