SPRTN is a new player in an old story

Nat Genet. 2014 Nov;46(11):1155-7. doi: 10.1038/ng.3125.

Abstract

A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome. The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / genetics*
  • DNA-Binding Proteins / genetics*
  • Genomic Instability / genetics*
  • Humans
  • Liver Neoplasms / genetics*
  • Male
  • Progeria / genetics*

Substances

  • DNA-Binding Proteins
  • SPRTN protein, human