A role for interleukin-22 in the alleviation of metabolic syndrome

Elise Dalmas; Marc Y Donath

doi:10.1038/nm.3748

A role for interleukin-22 in the alleviation of metabolic syndrome

Nat Med. 2014 Dec;20(12):1379-81. doi: 10.1038/nm.3748. Epub 2014 Nov 2.

Authors

Elise Dalmas¹, Marc Y Donath¹

Affiliation

¹ Clinic of Endocrinology, Diabetes and Metabolism, and the Department of Biomedicine, University of Basel, Basel, Switzerland.

PMID: 25362255
DOI: 10.1038/nm.3748

Abstract

Increasing evidence points to a role for the immune system in the regulation of metabolism. Two new studies in mice indicate treatment with interleukin-22 restores mucosal immunity in diabetes and alleviates metabolic disease, resulting in improved glycemic control.

Publication types

Comment

MeSH terms

Animals
Blood Glucose / metabolism*
Cytokines / immunology*
Diabetes Mellitus, Type 2 / immunology*
Endoplasmic Reticulum Stress / immunology*
Gene Expression Regulation / immunology*
Humans
Insulin / metabolism*
Insulin Secretion
Insulin-Secreting Cells / immunology*

Substances

Blood Glucose
Cytokines
Insulin