The wear performances of bovine tooth enamel (BTE) against translucent tetragonal zirconia polycrystals (TZP) compared to that of feldspar porcelain and the influence of surface treatments of translucent TZP were investigated by the two-body wear test. Translucent TZP and feldspar porcelain were used as hemisphere abrader specimens with a radius of curvature of 5 mm; flat BTE surfaces were used as substrate specimens. The cross-sectional area of the worn surfaces of the substrates and the wear volume of the antagonist abraders were measured. Surface roughness, hardness and coefficient of friction as well as SEM observations and EPMA analyses were also performed to investigate the underlying mechanism of wear. The results suggested that BTE is less susceptible to wear when translucent TZP is used as the antagonist in contrast to the use of feldspar porcelain, and that surface treatment of the TZP abraders significantly influenced the wear of BTE substrates.