Purpose: To investigate the characteristics of eyes in which a serous retinal detachment became substantially more extensive and persisted 1 week after photodynamic therapy (PDT) using indocyanine green (ICG) angiography.
Design: Retrospective, interventional case series.
Patients and methods: The authors reviewed the ICG angiograms of five eyes of five patients with neovascular age-related macular degeneration.
Results: In all eyes, the ICG angiograms obtained 1 week after PDT showed a well-demarcated hypofluorescent area corresponding to the treatment spot. Vascular hyperpermeability emanating from the middle and large choroidal vessels was seen within the hypofluorescent area whether the targeted choroidal neovascularization was perfused or not.
Conclusions: Choroidal vascular hyperpermeability on ICG angiography is a common finding in eyes with substantially increased subretinal fluid 1 week after PDT. PDT might even affect the middle and large choroidal vessels within the treatment spots under some conditions, leading to a supply of subretinal fluid and causing a persistent serous retinal detachment.