Epistasis analysis using multifactor dimensionality reduction

Methods Mol Biol. 2015:1253:301-14. doi: 10.1007/978-1-4939-2155-3_16.

Abstract

Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the key functions of the open-source MDR software package that is freely distributed. We end with a few examples of published studies of complex human diseases that have used MDR.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Case-Control Studies
  • Epistasis, Genetic*
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Multifactor Dimensionality Reduction / methods*
  • Quantitative Trait, Heritable
  • Statistics as Topic
  • Stochastic Processes
  • Urinary Bladder Neoplasms / genetics