Survival of AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma Cohort

Br J Haematol. 2015 Mar;168(6):806-10. doi: 10.1111/bjh.13221. Epub 2014 Nov 17.

Abstract

Overall survival (OS) of patients with acquired immunodeficiency syndrome (AIDS)-related Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL) was analysed in the German AIDS-related-Lymphoma-Cohort-Study. Of 291 patients prospectively included between January 2005 and December 2012, 154 had DLBCL, 103 BL and 34 PBL. Two-year OS rates were similar between BL (69%) and DLBCL patients (63%) but lower for PBL patients (43%). Intermediate (Hazard ratio [HR] 4·1 95% confidence interval [CI] 1·98-8·49) or high (HR 4·92 95% CI 2·1-11·61) International Prognostic Index, bone marrow involvement (HR 1·69 95% CI 1·00-2·84) and PBL histology (HR 2·24 95% CI 1·24-4·03) were independent predictors of mortality.

Keywords: AIDS-related Burkitt lymphoma; AIDS-related diffuse large B-cell-lymphoma; AIDS-related lymphoma; AIDS-related plasmablastic lymphoma; lymphoma.

Publication types

  • Comparative Study
  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Burkitt Lymphoma / diagnosis
  • Burkitt Lymphoma / immunology
  • Burkitt Lymphoma / mortality*
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Female
  • Germany / epidemiology
  • HIV-1*
  • Humans
  • Kaplan-Meier Estimate
  • Lymphoma, AIDS-Related / diagnosis
  • Lymphoma, AIDS-Related / immunology
  • Lymphoma, AIDS-Related / mortality*
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / immunology
  • Lymphoma, Large B-Cell, Diffuse / mortality*
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Young Adult